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Wegener Granulomatosis - Granulomatosis Symptoms & Treatment of Granulomatosis

Although a rare kind of disease, Wegener's Granulomatosis is a disease, more popularly known as the autoimmune disorder and should not escape our very knowing that such a disease have long existed even before its discoverer, Dr. Friedrich Wegener, have mentioned it in 1963. We indeed have come a long way, as far as medical science is concerned, from Dr. Wegener's time, yet ironically, doctors are still puzzled on what really causes granulomatosis. What we know, however, is that this disease affects a large part of our upper body, that is, the kidneys, lungs, sinuses, nose, and trachea and can eventually spread to other parts of the body including the nervous system, heart, eyes, ears, and skin.

Medically known as a form of vasculitis, the disease have been pointed out by some medical practitioners as being caused by inflammation of the veins and small arteries. This is practically evident among middle-aged and young adults and even children who encounter a serious type of antibody circulation in the blood vessels. Risks could also lead to microscopic polyangitis and Churg-Strauss syndrome, which seem to be advanced types of complications.

 

Granulomatosis Symptoms & Alternative Treatments for Granulomatosis


Granulomatosis comes with a horde of signs and symptoms. From the eye, ear, and upper airway, nosebleeds, pain, stuffiness, saddle-nose deformity, rhinitis, upper respiratory tract infection, hearing loss, (ear) scleritis, conjunctivitis, episcleritis, pseudotumors, (eye), subglottal stenosis, pulmonary nodules, cavitary lesions, pulmonary hemorrhage and bronchal stenosis (upper airway) are what's oftentimes noticeable. If the disease spreads to the kidney, patients would suffer from chronic renal failure. Pain and swelling in the joints or what we commonly known as arthritis are also felt by the infected. In the skin, it appears as nodules on the elbow while in the nervous system, patients are expected to suffer from the sensory neuropathy or the temporary loss of sensory functions and sometimes, mononeuritis multiplex. There is a consolation, though: the brain, heart, and the gastrointestinal tract are rarely affected.
    
For treatment, doctors would generally recommend corticosteroids and oral cyclophosphamide for usually 3 to 6 months. If this works, it is followed by medications such as azathioprine or methotrexate. With treatment often lasting for a year, high-risk patients are advised to be consistent with the dosage most of which comes under prescription and the assistance of a medical professional. Treatment will depend on the severity of the disease, such that it will need further medication like plasmapheresis. Most of these drugs were designed to suppress the activity of the immune system. Thus, more care has to be stressed because a variety of diseases may crop up when this one's in check.

There are also alternative treatments, which includes drugs like Rituximab, Chlorambucil, and Mycophenolate mofetil. Other kinds of treatments include the non-immunosuppressive type where co-trimoxazole, folic acid, and intravenous immunoglobulin are among the choice of most doctors. Patients who usually encounter severe stenosis on the glottal region of the body is required to take tracheotomy to maintain a passage of air into lungs.

 
   
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