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Causes and Cures for Pemphigus Vulgaris

One of the rare skin abnormalities that affect the skin and the mucous membranes is known as Pemphigus vulgaris. The skin disorder brings with it painful skin blisters in sensitive regions of the body where not only the area is difficult to heal but also causes a lot of discomfort to the patient. Pemphigus vulgaris belongs to a group of Pemphigus skin disorders, and it is the most common and pronounced form of the group.

Pemphigus normally takes place in adults who are above the age of 30 but this condition is also known to affect young children and adults below the age of 30. The disorder is not specific to any race or culture and can occur among both genders equally. According to research however, it has shown been discovered that pemphigus vulgaris is widely seen among adults in the Middle Eastern region or those belonging to the Jewish descent.

Pemphigus vulgaris is a chronic condition and the only way to treat it would be to start controlling the symptoms in the initial stages after the diagnosis. The type of medications used for treatment involves similar products that are used to treat severe burns. If Pemphigus vulgaris is left without any treatment it can prove to be fatal. The blisters that form either in the mouth, mucous membranes or genital regions get ruptured just as easily as they form and they are likely to get further infected if left without proper dressing and treatment. However the blisters are not known to itch.

The real cause of this disorder is not known to medical research; however, it seems to be a case of autoimmune disease. In the case of Pemphigus vulgaris, the immune system starts to counteract specific proteins in healthy skin cells in the skin tissues or the mucous membranes. These particular type of proteins known as desmogleins are critical in binding skin cells to each other, in a normal human body.

When Pemphigus vulgaris occurs, the antibodies start to attack the desmogleins and the skin cells begin to separate from each other. The epidermis is thus greatly affected as top most layer of skin starts to disintegrate. The process of skin disintegration is known acantholysis. Other symptoms accompanying the blisters include high temperature, body chills, a rapid spread in the number of blisters formed, aching muscles and joints, a general feeling of malaise.
Since the skin condition is rare it sometimes is difficult to detect, hence a skin biopsy and medical history is imperative if faced with these symptoms. Treatment of Pemphigus vulgaris includes a combination of corticosteroids, immunosuppressants, antibiotics and antifungal medications.